MiTF Monoclonal Mouse Antibody [Clone: D5] with BSA, 0.2mg/mL - 100 ul

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    MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. Anti-MITF, D5, recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.


    Antibody reactivity (target): MiTF


    Antibody type: Primary


    Host species: Mouse


    Clonality: Monoclonal


    Clone: D5


    Isotype: IgG1, kappa


    Molecular weight: 52-56 kDa (doublet)


    Synonyms: BHLHE32; Class E basic helix-loop-helix protein 32 (bHLHe32); CMM8; Mi; Microphthalmia-associated transcription factor; MITF; WS2; WS2A


    Human gene symbol: MITF


    Entrez gene ID: 4286


    SwissProt: O75030


    Unigene: 166017 & 618266


    Immunogen: NH2 terminus fragment of human Mi protein


    Antibody target cellular localization: Nucleus


    Verified antibody applications: IHC (FFPE) (verified)


    Species reactivity: Human


    Shipping conditions: Room temperature


    Storage Conditions: at 2 to 8 °C, Protect fluorescent conjugates from light, Note: store BSA-free antibodies at -10 to -35 °C


    Shelf life: Guaranteed for at least 24 months from date of receipt when stored as recommended


    Regulatory status: For research use only (RUO)