MiTF Monoclonal Mouse Antibody [Clone: D5] with BSA, 0.2mg/mL - 100 ul
(0 review)

£ 346.80 346.8 GBP £ 346.80 VAT Excluded

408.00 € VAT Excluded

Not Available For Sale

    This combination does not exist.

    Terms and Conditions
    30-day money-back guarantee
    Shipping: 2-3 Business Days

    MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. Anti-MITF, D5, recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.

    Antibody reactivity (target): MiTF

    Antibody type: Primary

    Host species: Mouse

    Clonality: Monoclonal

    Clone: D5

    Isotype: IgG1, kappa

    Molecular weight: 52-56 kDa (doublet)

    Synonyms: BHLHE32; Class E basic helix-loop-helix protein 32 (bHLHe32); CMM8; Mi; Microphthalmia-associated transcription factor; MITF; WS2; WS2A

    Human gene symbol: MITF

    Entrez gene ID: 4286

    SwissProt: O75030

    Unigene: 166017 & 618266

    Immunogen: NH2 terminus fragment of human Mi protein

    Antibody target cellular localization: Nucleus

    Verified antibody applications: IHC (FFPE) (verified)

    Species reactivity: Human

    Shipping conditions: Room temperature

    Storage Conditions: at 2 to 8 °C, Protect fluorescent conjugates from light, Note: store BSA-free antibodies at -10 to -35 °C

    Shelf life: Guaranteed for at least 24 months from date of receipt when stored as recommended

    Regulatory status: For research use only (RUO)